Abstract :Objective To investigate the effect of Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) combined with narrow-spectrum red light irradiation on postoperative wound healing and serum epidermal growth factor (EGF) and interleukin-33 (IL-33) levels in patients with perianal abscess. Methods A total of 96 patients with perianal abscess treated in Sun Simiao Hospital of Beijing University of Chinese Medicine/Tongchuan Traditional Chinese Medicine Hospital from February to June 2022 were selected as the research subjects and divided into a control group and a study group by random number table method, with 48 cases in each group. Both groups underwent incision and drainage for perianal abscess. The control group received conventional antibacterial drugs for anti-infection treatment after surgery. The study group received Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) combined with narrow-spectrum red light irradiation on the basis of the control group. The clinical efficacy, wound healing and health status survey short form (SF-36) scores after treatment, as well as serum EGF and IL-33 levels before and after treatment were compared between the two groups. Results After treatment, the total effective rate of the study group (93.75%) was significantly higher than that of the control group (77.08%), and the difference was statistically significant (P<0.05). After treatment, the scores of wound granulation tissue growth, wound secretion and visual analogue scale (VAS) in the study group were significantly lower than those in the control group, and the wound healing time was significantly shorter than that in the control group, with statistically significant differences (P<0.05). After treatment, the scores of physical health, mental health, social function and daily life in both groups were significantly higher than those before treatment, and the scores in the study group were significantly higher than those in the control group after treatment, with statistically significant differences (P<0.05). After treatment, the serum EGF level in both groups was significantly increased, and the IL-33 level was significantly decreased, with statistically significant differences compared with before treatment (P<0.05). After treatment, the EGF level in the study group was significantly higher than that in the control group, and the IL-33 level was significantly lower than that in the control group, with statistically significant differences (P<0.05). Conclusion Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) combined with narrow-spectrum red light irradiation is beneficial to wound healing in patients with perianal abscess, can relieve postoperative pain of perianal abscess, increase serum EGF level, reduce IL-33 level, improve the quality of life of patients, and has significant clinical efficacy.
Chen Jing, Hui Tong. Effects of compound polymyxin B ointment combined with narrow-spectrum red light irradiation on postoperative wound healing and serum EGF and IL-33 levels in patients with perianal abscess[J]. Laboratory Medicine and Clinic, 2023, 20(22): 3328-3331+3335.