Abstract:Objective To observe the clinical efficacy and safety of light emitting diode (LED) red light combined with recombinant human acidic fibroblast growth factor and Fonow ointment (Compound Polymyxin B Ointment, Triple Antibiotic Ointment) in the treatment of elderly patients with refractory skin ulcers. Methods The clinical data of 58 cases of elderly patients with refractory skin ulcers were retrospectively analyzed from February 2018 to October 2020, and were divided into the experimental group and the control group according to the different treatment methods, with 29 patients in each group. The control group was given routine surgical debridement and dressing change, after spraying topical recombinant human acidic fibroblast epidermal growth factor topical solution, topical Fonow ointment (Compound Polymyxin B Ointment, Triple Antibiotic Ointment), the frequency of dressing change in the early stage was 2~3 times/d, after the wound was improved, the frequency of dressing change was changed to 1 dressing change in an interval of 2~3 d. The experimental group was united with LED irradiation on the basis of the control group with a wavelength of (633±10) nm, a power density of 80~ 100 mW/cm~2, irradiation time 20 min, irradiation frequency and drug change frequency synchronization, the early frequency of 2 ~ 3 times / d, after the wound is improved, changed to the interval of 2 ~ 3 d irradiation once, a total of 4 weeks for a course of treatment. One week after a course of treatment, measure the size of the ulcer area of the two groups of patients, and carry out quality of life scores to determine the clinical efficacy. The incidence of adverse reactions was also recorded. Results Comparison of the ulcer area and quality of life scores of the two groups of patients before treatment showed no statistically significant difference (P>0.05). One week after treatment, the ulcer area of patients in the experimental group was significantly lower than that before treatment (P<0.05), and the quality of life score was significantly higher than that before treatment (P<0.05); although the ulcer area and the quality of life score of patients in the control group improved to different degrees after treatment compared with that before treatment, the difference was not statistically significant compared with that before treatment (P>0.05). The total effective rate of the test group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). No obvious adverse reactions occurred in both groups. Conclusion LED red light combined with recombinant human acidic fibroblast growth factor and Fonow ointment (Compound Polymyxin B Ointment, Triple Antibiotic Ointment) has precise efficacy and good safety in treating elderly patients with refractory skin ulcers.
LI Tinghui, CHANG Chunjuan, QIN Ziyuan. Efficacy of LED combined with recombinant human acidic fibroblast growth factor and polymyxin B ointment in the treatment of refractory skin ulcers in the elderly[J]. Chinese Journal of Laser Medicine, 2022, 31 (03): 164-168.